Many think that vitamin intake is never enough and that the body can only benefit from a vitamin boost. Is that really the case? Actually not. Under most circumstances, a balanced diet already provides the required amount of vitamins, and the eventual surplus is just eliminated without this impacting the body in any significant way.

However, vitamin intoxication is possible and this condition is known as hypervitaminosis. Hyperavitaminosis is seen almost exclusively in children with an unbalanced diet and taking a lot of supplements or heavily fortified foods.

Due to chemical properties, an excess of vitamins can only be witnessed with certain vitamins, while it's virtually impossible with others, given their high turnover and short half-life.

Which of the following vitamins is most likely to be associated with toxicity (hyoervitaminosis) following excessive intake:

The majority got it right again. An excessive intake of vitamin A is much more likelier to lead to a symptomatic overload, compared to the others, due to its fat-soluble nature, which makes it stay in the body for longer. A similar reasoning applies to vitamin D.

Hypervitaminosis A usually happens as a consequence of excessive assumption of food supplements (megavitamin therapy).

Sometimes it can be witnessed in people eating large amounts of animal liver and derivatives. Certain drugs used in severe acne, such as isotretinoin, can cause it too, as they contains large amounts of retenyl esters.

Hypervitaminosis A is _not_ caused by high consumption of food rich of provitamin A carotenoids (vegetables).

Symptoms include drowsiness, confusion, irritability, headache, nausea, blurry vision, sun sensitivity, eczema, mouth ulcers, and bone fragility.
The condition is considered benign and under most circumstances resolves with supplement interruption.

Compared to hypervitaminosis, vitamin A deficiency is much more common world-wide, especially among children in 'developing' countries. Elsewhere it's mainly seen as a consequence of GI malabsorption and sometimes renal disease.

@encelado Paracelsus' principle applies yet again. "The dose makes the poison".

@encelado on that subject..

"There is also some evidence that people are overdoing vitamin D supplementation on their own. Researchers looking at national survey data gathered from 1999 to 2014 found a 2.8% uptick in the number of people taking potentially unsafe amounts of vitamin D — that is, more than 4,000 IU per day, according to a 2017 research letter published in JAMA. And during the same time period, the number of people taking 1,000 IU or more of vitamin D daily increased nearly 18%."

@epoch thanks for sharing! I indeed didn't put Vitamin D in the poll (which you're invited to participate to :3), because then I should have allowed multiple choices.

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